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IGJ Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P01591
Clone Names 80917009
Peptide ID 80917009
Additional Information
Other Names Immunoglobulin J chain, IGJ, IGCJ
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6548a was selected from the N-term region of human IGJ. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name JCHAIN (HGNC:5713)
Synonyms IGCJ, IGJ
Function Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.
Cellular Location Secreted {ECO:0000250|UniProtKB:P01592}. EMBL; AK312014; BAG34952.1; -; mRNA EMBL; M12759; AAA58902.1; -; Genomic_DNA EMBL; M12378; AAA58902.1; JOINED; Genomic_DNA CCDS; CCDS3545.1; - PIR; A01859; JIHU RefSeq; NP_653247.1; NM_144646.3 RefSeq; XP_006714274.1; XM_006714211.2 RefSeq; XP_006714275.1; XM_006714212.2 RefSeq; XP_011530227.1; XM_011531925.1 RefSeq; XP_011530228.1; XM_011531926.1 UniGene; Hs.643431; - ProteinModelPortal; P01591; - BioGrid; 109732; 19 IntAct; P01591; 4 STRING; 9606.ENSP00000254801; - iPTMnet; P01591; - PhosphoSitePlus; P01591; - UniCarbKB; P01591; - BioMuta; IGJ; - SWISS-2DPAGE; P01591; - EPD; P01591; - MaxQB; P01591; - PaxDb; P01591; - PeptideAtlas; P01591; - PRIDE; P01591; - Ensembl; ENST00000254801; ENSP00000254801; ENSG00000132465 Ensembl; ENST00000510437; ENSP00000426687; ENSG00000132465 Ensembl; ENST00000543780; ENSP00000440066; ENSG00000132465 GeneID; 3512; - KEGG; hsa:3512; - UCSC; uc003hfn.5; human CTD; 3512; - DisGeNET; 3512; - GeneCards; JCHAIN; - HGNC; HGNC:5713; JCHAIN HPA; CAB034436; - HPA; HPA044132; - MIM; 147790; gene neXtProt; NX_P01591; - OpenTargets; ENSG00000132465; - PharmGKB; PA29733; - eggNOG; ENOG410IYAZ; Eukaryota eggNOG; ENOG410YX96; LUCA GeneTree; ENSGT00390000012791; - HOGENOM; HOG000113012; - HOVERGEN; HBG006138; - InParanoid; P01591; - OMA; KCYTNRV; - OrthoDB; EOG091G0RP0; - PhylomeDB; P01591; - TreeFam; TF335878; - BioCyc; ZFISH:ENSG00000132465-MONOMER; - Reactome; R-HSA-2168880; Scavenging of heme from plasma ChiTaRS; IGJ; human GeneWiki; IGJ; - GenomeRNAi; 3512; - PRO; PR:P01591; - Proteomes; UP000005640; Chromosome 4 Bgee; ENSG00000132465; - CleanEx; HS_IGJ; - ExpressionAtlas; P01591; baseline and differential Genevisible; P01591; HS GO; GO:0072562; C:blood microparticle; IDA:UniProtKB GO; GO:0071750; C:dimeric IgA immunoglobulin complex; IMP:UniProtKB GO; GO:0070062; C:extracellular exosome; IDA:UniProtKB GO; GO:0005576; C:extracellular region; NAS:UniProtKB GO; GO:0005615; C:extracellular space; IDA:UniProtKB GO; GO:0071748; C:monomeric IgA immunoglobulin complex; IDA:UniProtKB GO; GO:0071756; C:pentameric IgM immunoglobulin complex; IDA:UniProtKB GO; GO:0071752; C:secretory dimeric IgA immunoglobulin complex; IDA:UniProtKB GO; GO:0071751; C:secretory IgA immunoglobulin complex; IDA:UniProtKB GO; GO:0003823; F:antigen binding; NAS:UniProtKB GO; GO:0019862; F:IgA binding; IMP:UniProtKB GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB GO; GO:0002250; P:adaptive immune response; IDA:UniProtKB GO; GO:0019731; P:antibacterial humoral response; IDA:UniProtKB GO; GO:0003094; P:glomerular filtration; IMP:UniProtKB GO; GO:0006955; P:immune response; NAS:UniProtKB GO; GO:0045087; P:innate immune response; IDA:UniProtKB GO; GO:0032461; P:positive regulation of protein oligomerization; IMP:UniProtKB GO; GO:0060267; P:positive regulation of respiratory burst; IDA:UniProtKB GO; GO:0006898; P:receptor-mediated endocytosis; TAS:Reactome GO; GO:0001895; P:retina homeostasis; IEP:UniProtKB InterPro; IPR024110; Ig_J PANTHER; PTHR10070; PTHR10070; 1 Pfam; PF15097; Ig_J_chain; 1 ProDom; PD021296; PD021296; 1 1: Evidence at protein level; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal SIGNAL 1 22 CHAIN 23 159 Immunoglobulin J chain /FTId=PRO_0000084174 MOD_RES 23 23 Pyrrolidone carboxylic acid CARBOHYD 71 71 N-linked (GlcNAc...) (complex) /FTId=CAR_000167 DISULFID 35 123 DISULFID 37 37 Interchain (with heavy chain) DISULFID 91 91 Interchain (with heavy chain) DISULFID 94 114 DISULFID 131 156 SEQUENCE 159 AA; 18099 MW; B7835C02CCC0CB05 CRC64; MKNHLLFWGV LAVFIKAVHV KAQEDERIVL VDNKCKCARI TSRIIRSSED PNEDIVERNI RIIVPLNNRE NISDPTSPLR TRFVYHLSDL CKKCDPTEVE LDNQIVTATQ SNICDEDSAT ETCYTYDRNK CYTAVVPLVY GGETKMVETA LTPDACYPD
Research Areas
Citations (0)

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Background

IGJ serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.

References

Ramachandran,P., J. Proteome Res. 5 (6), 1493-1503 (2006)Liu,T., J. Proteome Res. 4 (6), 2070-2080 (2005)

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$ 80.00
Cat# BP6548a
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