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IGJ Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P01591 |
|---|---|
| Clone Names | 80917009 |
| Gene ID | 3512 |
|---|---|
| Other Names | Immunoglobulin J chain, IGJ, IGCJ |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6548a was selected from the N-term region of human IGJ. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | JCHAIN (HGNC:5713) |
|---|---|
| Synonyms | IGCJ, IGJ |
| Function | Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers. It also helps to bind these immunoglobulins to secretory component. |
| Cellular Location | Secreted {ECO:0000250|UniProtKB:P01592}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
IGJ serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.
References
Ramachandran,P., J. Proteome Res. 5 (6), 1493-1503 (2006)Liu,T., J. Proteome Res. 4 (6), 2070-2080 (2005)
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