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IGJ Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P01591
Clone Names 80917009
Peptide ID 80917009
Additional Information
Other Names Immunoglobulin J chain, IGJ, IGCJ
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6548a was selected from the N-term region of human IGJ. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name JCHAIN (HGNC:5713)
Synonyms IGCJ, IGJ
Function Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.
Cellular Location Secreted {ECO:0000250|UniProtKB:P01592}. EMBL; AK312014; BAG34952.1; -; mRNA EMBL; M12759; AAA58902.1; -; Genomic_DNA EMBL; M12378; AAA58902.1; JOINED; Genomic_DNA CCDS; CCDS3545.1; - PIR; A01859; JIHU RefSeq; NP_653247.1; NM_144646.3 RefSeq; XP_006714274.1; XM_006714211.2 RefSeq; XP_006714275.1; XM_006714212.2 RefSeq; XP_011530227.1; XM_011531925.1 RefSeq; XP_011530228.1; XM_011531926.1 UniGene; Hs.643431; - ProteinModelPortal; P01591; - BioGrid; 109732; 19 IntAct; P01591; 4 STRING; 9606.ENSP00000254801; - iPTMnet; P01591; - PhosphoSitePlus; P01591; - UniCarbKB; P01591; - BioMuta; IGJ; - SWISS-2DPAGE; P01591; - EPD; P01591; - MaxQB; P01591; - PaxDb; P01591; - PeptideAtlas; P01591; - PRIDE; P01591; - Ensembl; ENST00000254801; ENSP00000254801; ENSG00000132465 Ensembl; ENST00000510437; ENSP00000426687; ENSG00000132465 Ensembl; ENST00000543780; ENSP00000440066; ENSG00000132465 GeneID; 3512; - KEGG; hsa:3512; - UCSC; uc003hfn.5; human CTD; 3512; - DisGeNET; 3512; - GeneCards; JCHAIN; - HGNC; HGNC:5713; JCHAIN HPA; CAB034436; - HPA; HPA044132; - MIM; 147790; gene neXtProt; NX_P01591; - OpenTargets; ENSG00000132465; - PharmGKB; PA29733; - eggNOG; ENOG410IYAZ; Eukaryota eggNOG; ENOG410YX96; LUCA GeneTree; ENSGT00390000012791; - HOGENOM; HOG000113012; - HOVERGEN; HBG006138; - InParanoid; P01591; - OMA; KCYTNRV; - OrthoDB; EOG091G0RP0; - PhylomeDB; P01591; - TreeFam; TF335878; - BioCyc; ZFISH:ENSG00000132465-MONOMER; - Reactome; R-HSA-2168880; Scavenging of heme from plasma ChiTaRS; IGJ; human GeneWiki; IGJ; - GenomeRNAi; 3512; - PRO; PR:P01591; - Proteomes; UP000005640; Chromosome 4 Bgee; ENSG00000132465; - CleanEx; HS_IGJ; - ExpressionAtlas; P01591; baseline and differential Genevisible; P01591; HS GO; GO:0072562; C:blood microparticle; IDA:UniProtKB GO; GO:0071750; C:dimeric IgA immunoglobulin complex; IMP:UniProtKB GO; GO:0070062; C:extracellular exosome; IDA:UniProtKB GO; GO:0005576; C:extracellular region; NAS:UniProtKB GO; GO:0005615; C:extracellular space; IDA:UniProtKB GO; GO:0071748; C:monomeric IgA immunoglobulin complex; IDA:UniProtKB GO; GO:0071756; C:pentameric IgM immunoglobulin complex; IDA:UniProtKB GO; GO:0071752; C:secretory dimeric IgA immunoglobulin complex; IDA:UniProtKB GO; GO:0071751; C:secretory IgA immunoglobulin complex; IDA:UniProtKB GO; GO:0003823; F:antigen binding; NAS:UniProtKB GO; GO:0019862; F:IgA binding; IMP:UniProtKB GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB GO; GO:0002250; P:adaptive immune response; IDA:UniProtKB GO; GO:0019731; P:antibacterial humoral response; IDA:UniProtKB GO; GO:0003094; P:glomerular filtration; IMP:UniProtKB GO; GO:0006955; P:immune response; NAS:UniProtKB GO; GO:0045087; P:innate immune response; IDA:UniProtKB GO; GO:0032461; P:positive regulation of protein oligomerization; IMP:UniProtKB GO; GO:0060267; P:positive regulation of respiratory burst; IDA:UniProtKB GO; GO:0006898; P:receptor-mediated endocytosis; TAS:Reactome GO; GO:0001895; P:retina homeostasis; IEP:UniProtKB InterPro; IPR024110; Ig_J PANTHER; PTHR10070; PTHR10070; 1 Pfam; PF15097; Ig_J_chain; 1 ProDom; PD021296; PD021296; 1 1: Evidence at protein level; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal SIGNAL 1 22 CHAIN 23 159 Immunoglobulin J chain /FTId=PRO_0000084174 MOD_RES 23 23 Pyrrolidone carboxylic acid CARBOHYD 71 71 N-linked (GlcNAc...) (complex) /FTId=CAR_000167 DISULFID 35 123 DISULFID 37 37 Interchain (with heavy chain) DISULFID 91 91 Interchain (with heavy chain) DISULFID 94 114 DISULFID 131 156 SEQUENCE 159 AA; 18099 MW; B7835C02CCC0CB05 CRC64; MKNHLLFWGV LAVFIKAVHV KAQEDERIVL VDNKCKCARI TSRIIRSSED PNEDIVERNI RIIVPLNNRE NISDPTSPLR TRFVYHLSDL CKKCDPTEVE LDNQIVTATQ SNICDEDSAT ETCYTYDRNK CYTAVVPLVY GGETKMVETA LTPDACYPD
Research Areas
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IGJ serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.


Ramachandran,P., J. Proteome Res. 5 (6), 1493-1503 (2006)Liu,T., J. Proteome Res. 4 (6), 2070-2080 (2005)

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$ 80.00
Cat# BP6548a
Availability: In Stock
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