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VHL Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P40337
Clone Names 80902052
Peptide ID 80902052
Additional Information
Gene ID 7428
Other Names Von Hippel-Lindau disease tumor suppressor, Protein G7, pVHL, VHL
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6549a was selected from the N-term region of human VHL. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name VHL
Function Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.
Cellular Location Isoform 1: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=Found predominantly in the cytoplasm and with less amounts nuclear or membrane-associated Colocalizes with ADRB2 at the cell membrane
Tissue Location Expressed in the adult and fetal brain and kidney
Research Areas
Citations (0)

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Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of VHL gene is the basis of familial inheritance of VHL syndrome. The protein is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein.


Olmos,G., Cell. Mol. Life Sci. 66 (13), 2167-2180 (2009)Hatzimichael,E., Clin Lymphoma Myeloma 9 (3), 239-242 (2009)Luu,V.D., Clin. Cancer Res. 15 (10), 3297-3304 (2009)

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$ 80.00
Cat# BP6549a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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