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CRAT Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P43155
Clone Names 80513057
Additional Information
Gene ID 1384
Other Names Carnitine O-acetyltransferase, Carnitine acetylase, Carnitine acetyltransferase, CAT, CrAT, CRAT, CAT1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6565a was selected from the N-term region of human CRAT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CRAT (HGNC:2342)
Synonyms CAT1
Function Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta- oxidation (PubMed:15099582, PubMed:29395073). Responsible for the synthesis of short- and branched-chain acylcarnitines (PubMed:23485643). Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates (PubMed:23485643). Trans-2- enoyl-CoAs and 2-methylacyl-CoAs are poor substrates (PubMed:23485643).
Cellular Location Endoplasmic reticulum. Peroxisome. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side [Isoform 2]: Peroxisome
Tissue Location Mostly in skeletal muscle, less in heart, liver and pancreas, only weakly detectable in brain, placenta, lung and kidney
Research Areas
Citations (0)
citation

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Background

CRAT is carnitine acetyltransferase (CRAT), which is a key enzyme in the metabolic pathway in mitochondria, peroxisomes and endoplasmic reticulum. CRAT catalyzes the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acylCoA/CoA in the subcellular compartments.

References

Govindasamy,L., J. Struct. Biol. 146 (3), 416-424 (2004)Jogl,G., Cell 112 (1), 113-122 (2003)

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$ 277.78
Cat# BP6565a
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