|Other Names||Endonuclease G, mitochondrial, Endo G, 3130-, ENDOG|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6571b was selected from the C-term region of human ENDOG. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
ENDOG is a nuclear encoded endonuclease that is localized in the mitochondrion. The protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA.
Noda,T., Apoptosis 14 (3), 287-297 (2009)Wu,S.L., J. Biomed. Sci. 16, 6 (2009)Ahn,C.H., APMIS 116 (6), 534-537 (2008)
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