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GZMB Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P10144
Clone Names 80513179
Peptide ID 80513179
Additional Information
Gene ID 3002
Other Names Granzyme B, C11, CTLA-1, Cathepsin G-like 1, CTSGL1, Cytotoxic T-lymphocyte proteinase 2, Lymphocyte protease, Fragmentin-2, Granzyme-2, Human lymphocyte protein, HLP, SECT, T-cell serine protease 1-3E, GZMB, CGL1, CSPB, CTLA1, GRB
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6575a was selected from the N-term region of human GZMB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CGL1, CSPB, CTLA1, GRB
Function This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Cellular Location Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells
Research Areas
Citations (0)

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Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.


Hagn,M., J. Immunol. 183 (3), 1838-1845 (2009)Gaafar,A., Exp. Hematol. 37 (7), 838-848 (2009)Girnita,D.M., Transplantation 87 (12), 1801-1806 (2009)

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$ 80.00
Cat# BP6575a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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