|Other Names||Granzyme H, 3421-, CCP-X, Cathepsin G-like 2, CTSGL2, Cytotoxic T-lymphocyte proteinase, Cytotoxic serine protease C, CSP-C, GZMH, CGL2, CTSGL2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6576a was selected from the N-term region of human GZMH. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.|
|Cellular Location||Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes|
|Tissue Location||Constituvely expressed in NK cells.|
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Provided below are standard protocols that you may find useful for product applications.
GZMH is probably necessary for target cell lysis in cell-mediated immune responses.
Romero,V., Cell Death Differ. 16 (2), 340-348 (2009)Hou,Q., Mol. Immunol. 45 (4), 1044-1055 (2008)Waterhouse,N.J., Trends Immunol. 28 (9), 373-375 (2007)
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