GZMH Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P20718 |
---|---|
Clone Names | 80513181 |
Gene ID | 2999 |
---|---|
Other Names | Granzyme H, 3421-, CCP-X, Cathepsin G-like 2, CTSGL2, Cytotoxic T-lymphocyte proteinase, Cytotoxic serine protease C, CSP-C, GZMH, CGL2, CTSGL2 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6576a was selected from the N-term region of human GZMH. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GZMH |
---|---|
Synonyms | CGL2, CTSGL2 |
Function | Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication. |
Cellular Location | Cytolytic granule. |
Tissue Location | Constitutively expressed in NK cells. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
GZMH is probably necessary for target cell lysis in cell-mediated immune responses.
References
Romero,V., Cell Death Differ. 16 (2), 340-348 (2009)Hou,Q., Mol. Immunol. 45 (4), 1044-1055 (2008)Waterhouse,N.J., Trends Immunol. 28 (9), 373-375 (2007)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.