Calponin-3 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q15417 |
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Clone Names | 80808072 |
Gene ID | 1266 |
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Other Names | Calponin-3, Calponin, acidic isoform, CNN3 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6581c was selected from the Center region of human Calponin-3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CNN3 |
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Function | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. |
Tissue Location | Expressed in both non-smooth muscle tissues as well as smooth muscle tissues |
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Provided below are standard protocols that you may find useful for product applications.
Background
Calponin-3 is a protein with a markedly acidic C terminus; the basic N-terminus is highly homologous to the N-terminus of a related gene, CNN1. This protein is associated with the cytoskeleton but is not involved in contraction.
References
Vinatzer,U., Clin. Cancer Res. 14 (20), 6426-6431 (2008)Haag,J., Exp. Cell Res. 313 (16), 3386-3394 (2007)
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