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COL6A1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P12109 |
|---|---|
| Clone Names | 81006038 |
| Gene ID | 1291 |
|---|---|
| Other Names | Collagen alpha-1(VI) chain, COL6A1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6587b was selected from the C-term region of human COL6A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | COL6A1 |
|---|---|
| Function | Collagen VI acts as a cell-binding protein. |
| Cellular Location | Secreted, extracellular space, extracellular matrix |
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Provided below are standard protocols that you may find useful for product applications.
Background
The collagens are a superfamily of proteins that play a role in maintaining the integrity of various tissues. Collagens are extracellular matrix proteins and have a triple-helical domain as their common structural element. Collagen VI is a major structural component of microfibrils. The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The protein COL6A1 is the alpha 1 subunit of type VI collagen (alpha1(VI) chain). Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy.
References
Martoni,E., Hum. Mutat. 30 (5), E662-E672 (2009)Kim,T.H., J. Rheumatol. 35 (9), 1849-1852 (2008)Fujita,A., Genet. Mol. Res. 7 (2), 371-378 (2008)
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