|Other Names||Nocturnin, Carbon catabolite repression 4-like protein, Circadian deadenylase NOC, CCRN4L, CCR4, NOC|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6611b was selected from the C-term region of human CCRN4L. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase- independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity).|
|Cellular Location||Cytoplasm. Nucleus. Cytoplasm, perinuclear region|
|Tissue Location||Adipose tissue. Expression is higher in subcutaneous adipose tissue as compared to visceral adipose tissue.|
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Provided below are standard protocols that you may find useful for product applications.
CCRN4L is highly similar to Nocturnin, identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4).
Nakamura,E.S., Clin. Exp. Metastasis 23 (1), 9-18 (2006)
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