|Other Names||T-complex protein 1 subunit zeta, TCP-1-zeta, Acute morphine dependence-related protein 2, CCT-zeta-1, HTR3, Tcp20, CCT6A, CCT6, CCTZ|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6612c was selected from the Center region of human CCT6A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.|
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Provided below are standard protocols that you may find useful for product applications.
CCT6A is a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin.
Kubota,H., Curr. Biol. 4 (2), 89-99 (1994)
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