|Other Names||SHC-transforming protein 2, Protein Sck, SHC-transforming protein B, Src homology 2 domain-containing-transforming protein C2, SH2 domain protein C2, SHC2, SCK, SHCB|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6621a was selected from the N-term region of human SHC2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).|
|Tissue Location||Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus|
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Provided below are standard protocols that you may find useful for product applications.
SHC2 is a signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. It is involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
Liu,H.Y., J. Biol. Chem. 277 (29), 26046-26056 (2002)
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