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STXBP1 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P61764
Additional Information
Gene ID 6812
Other Names Syntaxin-binding protein 1, MUNC18-1, N-Sec1, Protein unc-18 homolog 1, Unc18-1, Protein unc-18 homolog A, Unc-18A, p67, STXBP1, UNC18A
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name STXBP1
Synonyms UNC18A
Function Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes (By similarity). May play a role in determining the specificity of intracellular fusion reactions.
Cellular Location Cytoplasm, cytosol. Membrane; Peripheral membrane protein
Tissue Location Brain and spinal cord. Highly enriched in axons.
Research Areas
Citations (0)
citation

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Background

STXBP1 encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor.

References

Sultana, R., et al. Antioxid. Redox Signal. 12(3):327-336(2010)Hamdan, F.F., et al. Ann. Neurol. 65(6):748-753(2009)Behan, A.T., et al. Mol. Psychiatry 14(6):601-613(2009)

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$ 277.78
Cat# BP6623a
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