|Other Names||Syntaxin-binding protein 1, MUNC18-1, N-Sec1, Protein unc-18 homolog 1, Unc18-1, Protein unc-18 homolog A, Unc-18A, p67, STXBP1, UNC18A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.|
|Cellular Location||Cytoplasm, cytosol. Membrane; Peripheral membrane protein|
|Tissue Location||Brain and spinal cord. Highly enriched in axons|
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Provided below are standard protocols that you may find useful for product applications.
STXBP1 encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor.
Sultana, R., et al. Antioxid. Redox Signal. 12(3):327-336(2010)Hamdan, F.F., et al. Ann. Neurol. 65(6):748-753(2009)Behan, A.T., et al. Mol. Psychiatry 14(6):601-613(2009)
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