TIEG2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O14901 |
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Clone Names | 80924247 |
Gene ID | 8462 |
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Other Names | Krueppel-like factor 11, Transforming growth factor-beta-inducible early growth response protein 2, TGFB-inducible early growth response protein 2, TIEG-2, KLF11, FKLF, TIEG2 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6625a was selected from the N-term region of human TIEG2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | KLF11 |
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Synonyms | FKLF, TIEG2 |
Function | Transcription factor (PubMed:9748269, PubMed:10207080). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity). |
Cellular Location | Nucleus. |
Tissue Location | Ubiquitous. Higher expression in erythroid cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
TIEG2 is a transcription factor. The protein activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. It represses transcription of SMAD7 which enhances TGF-beta signaling. It induces apoptosis.
References
Kuroda,E., Endocr. J. 56 (2), 275-286 (2009)Ma,L., J. Clin. Endocrinol. Metab. 93 (9), 3644-3649 (2008)
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