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BUB3 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O43684
Clone Names 80924085
Additional Information
Gene ID 9184
Other Names Mitotic checkpoint protein BUB3, BUB3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6629b was selected from the C-term region of human BUB3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BUB3
Function Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.
Cellular Location Nucleus. Chromosome, centromere, kinetochore. Note=Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I- anaphase I (MI-AI) transition.
Research Areas
Citations (0)
citation

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Background

BUB3 is a protein involved in spindle checkpoint function. The protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein.

References

Vernole,P., Cell Cycle 8 (3), 421-429 (2009)Logarinho,E., Mol. Biol. Cell 19 (4), 1798-1813 (2008)

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$ 277.78
Cat# BP6629b
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