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BUB3 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O43684
Clone Names 80924084
Peptide ID 80924084
Additional Information
Gene ID 9184
Other Names Mitotic checkpoint protein BUB3, BUB3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6629c was selected from the Center region of human BUB3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BUB3
Function Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.
Cellular Location Nucleus. Chromosome, centromere, kinetochore. Note=Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I-anaphase I (MI-AI) transition.
Research Areas
Citations (0)

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BUB3 is a protein involved in spindle checkpoint function. The protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein.


Vernole,P., Cell Cycle 8 (3), 421-429 (2009)Logarinho,E., Mol. Biol. Cell 19 (4), 1798-1813 (2008)

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$ 80.00
Cat# BP6629c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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