|Other Names||Glutaminase liver isoform, mitochondrial, GLS, L-glutaminase, L-glutamine amidohydrolase, GLS2, GA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.|
|Tissue Location||Highly expressed in liver. Expressed in brain and pancreas. Not observed in heart, placenta, lung, skeletal muscle and kidney. Expression is significantly reduced in hepatocellular carcinomas.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a mitochondrialphosphate-activated glutaminase that catalyzes the hydrolysis ofglutamine to stoichiometric amounts of glutamate and ammonia. Thisprotein is functionally similar to the kidney glutaminase but is alittle smaller in size. Originally thought to be liver-specific,this protein has been found in other tissues as well. At least onetranscribed pseudogene has been found for this gene. [provided byRefSeq].
Hu, W., et al. Proc. Natl. Acad. Sci. U.S.A. 107(16):7455-7460(2010)Suzuki, S., et al. Proc. Natl. Acad. Sci. U.S.A. 107(16):7461-7466(2010)Szeliga, M., et al. Glia 57(9):1014-1023(2009)Tian, C., et al. J. Neurochem. 105(3):994-1005(2008)Maeshima, H., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry 31(7):1410-1418(2007)
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