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NKRF Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O15226
Clone Names 80917093
Additional Information
Gene ID 55922
Other Names NF-kappa-B-repressing factor, NFkB-repressing factor, Protein ITBA4, Transcription factor NRF, NKRF, ITBA4, NRF
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6660c was selected from the Center region of human NKRF. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NKRF {ECO:0000303|PubMed:32179686, ECO:0000312|HGNC:HGNC:19374}
Function Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793). Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity (PubMed:12381793). Also involved in the regulation of IL-8 transcription (PubMed:12381793). May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes (PubMed:10562553).
Cellular Location Nucleus, nucleolus.
Tissue Location Widely and constitutively expressed (PubMed:10562553). Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney (PubMed:10562553)
Research Areas
Citations (0)
citation

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Background

NKRF is a transcription factor that interacts with specific negative regulatory elements (NREs) to mediate transcriptional repression of certain NK-kappa-B-responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm.

References

Ho,S.C., J. Immunol. 183 (1), 411-420 (2009)Glanz,A., Immunol. Cell Biol. 86 (7), 622-630 (2008)

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$ 277.78
Cat# BP6660c
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Availability: 2 weeks
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