|Other Names||Prolargin, Proline-arginine-rich end leucine-rich repeat protein, PRELP, SLRR2A|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6665b was selected from the C-term region of human PRELP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May anchor basement membranes to the underlying connective tissue.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Connective tissue.|
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Provided below are standard protocols that you may find useful for product applications.
PRELP is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage.
Grover,J., Matrix Biol. 26 (2), 140-143 (2007)Johnson,J.M., Mol. Vis. 12, 1057-1066 (2006)Lewis,M., Ageing Res. Rev. 2 (1), 95-105 (2003)
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