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PRELP Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P51888
Peptide ID 30007
Additional Information
Gene ID 5549
Other Names Prolargin, Proline-arginine-rich end leucine-rich repeat protein, PRELP, SLRR2A
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRELP
Synonyms SLRR2A
Function May anchor basement membranes to the underlying connective tissue.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Connective tissue.
Research Areas
Citations (0)

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Background

PRELP is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage.

References

Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)Grover, J., et al. Matrix Biol. 26(2):140-143(2007)Johnson, J.M., et al. Mol. Vis. 12, 1057-1066 (2006)

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$ 80.00
Cat# BP6665c
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