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RAB13 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P51153
Clone Names 80924152
Peptide ID 80924152
Additional Information
Gene ID 5872
Other Names Ras-related protein Rab-13, Cell growth-inhibiting gene 4 protein, RAB13
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6667c was selected from the Center region of human RAB13. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RAB13
Function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin- induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis.
Cellular Location Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Cell junction, tight junction. Golgi apparatus, trans-Golgi network membrane. Recycling endosome membrane. Cell projection, lamellipodium. Cytoplasmic vesicle, secretory vesicle membrane. Note=Tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions. Relocalizes to the leading edge of lamellipodia in migrating endothelial cells
Tissue Location Detected in several types of epithelia, including intestine, kidney, liver and in endothelial cells
Research Areas
Citations (0)

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RAB13 can participate in polarized transport, in the assembly and/or the activity of tight junctions.


Nokes,R.L., J. Cell Biol. 182 (5), 845-853 (2008)Kanda,I., Oncogene 27 (12), 1687-1695 (2008)

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$ 80.00
Cat# BP6667c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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