|Other Names||Plasma protease C1 inhibitor, C1 Inh, C1Inh, C1 esterase inhibitor, C1-inhibiting factor, Serpin G1, SERPING1, C1IN, C1NH|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6673b was selected from the Center region of human SERPING1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Activation of the C1 complex is under control of the C1- inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.|
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Provided below are standard protocols that you may find useful for product applications.
SERPING1 is a highly glycosylated plasma protein involved in the regulation of the complement cascade. This protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE).
Park,K.H., Mol. Vis. 15, 200-207 (2009)Gosswein,T., Cytogenet. Genome Res. 121 (3-4), 181-188 (2008)
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