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Sestrin-2 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P58004
Clone Names 80902004
Peptide ID 80902004
Additional Information
Gene ID 83667
Other Names Sestrin-2, Hi95, SESN2, SEST2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6674c was selected from the Center region of human Sestrin-2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SESN2 (HGNC:20746)
Function Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26612684, PubMed:26586190). Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:26449471, PubMed:26586190). This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1 (PubMed:24947615). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468). Has an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (PubMed:26612684). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (PubMed:19113821).
Cellular Location Cytoplasm.
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Background

SESN2 is a member of the sestrin family of PA26-related proteins. The protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions.

References

Budanov,A.V., Science 304 (5670), 596-600 (2004)Peeters,H., Hum. Genet. 112 (5-6), 573-580 (2003)

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$ 80.00
Cat# BP6674c
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