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TALDO1 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P37837
Clone Names 80924231
Additional Information
Gene ID 6888
Other Names Transaldolase, TALDO1, TAL, TALDO, TALDOR
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6679c was selected from the Center region of human TALDO1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TALDO1 (HGNC:11559)
Synonyms TAL, TALDO, TALDOR
Function Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate (PubMed:8955144, PubMed:18687684). Not only acts as a pentose phosphate pathway enzyme, but also affects other metabolite pathways by altering its subcellular localization between the nucleus and the cytoplasm (By similarity).
Cellular Location [Isoform 1]: Nucleus {ECO:0000250|UniProtKB:Q93092}. Cytoplasm {ECO:0000250|UniProtKB:Q93092}. Note=Shuttles between the nucleus and the cytoplasm. Actively transported into the nucleus in an importin alpha/beta-dependent manner. Exported into the cytoplasm by CRM1 {ECO:0000250|UniProtKB:Q93092}
Research Areas
Citations (0)
citation

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Background

Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals.

References

Schneider,S., J. Biol. Chem. 283 (44), 30064-30072 (2008)Qian,Y., Biochem. J. 415 (1), 123-134 (2008)Wamelink,M.M., J. Inherit. Metab. Dis. 30 (5), 735-742 (2007)

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$ 277.78
Cat# BP6679c
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Availability: 2 weeks
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