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ZWINT Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O95229
Clone Names 80924299
Peptide ID 80924299
Additional Information
Gene ID 11130
Other Names ZW10 interactor, ZW10-interacting protein 1, Zwint-1, ZWINT
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6686b was selected from the C-term region of human ZWINT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase.
Cellular Location Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase
Research Areas
Citations (0)

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ZWINT is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells.


Famulski,J.K., J. Cell Biol. 180 (3), 507-520 (2008)Kops,G.J., J. Cell Biol. 169 (1), 49-60 (2005)Wang,H., J. Biol. Chem. 279 (52), 54590-54598 (2004)

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$ 80.00
Cat# BP6686b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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