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ZWINT Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O95229
Clone Names 80924298
Additional Information
Gene ID 11130
Other Names ZW10 interactor, ZW10-interacting protein 1, Zwint-1, ZWINT
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6686c was selected from the Center region of human ZWINT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZWINT
Function Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase.
Cellular Location Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase
Research Areas
Citations (0)
citation

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Background

ZWINT is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells.

References

Famulski,J.K., J. Cell Biol. 180 (3), 507-520 (2008)Kops,G.J., J. Cell Biol. 169 (1), 49-60 (2005)Wang,H., J. Biol. Chem. 279 (52), 54590-54598 (2004)

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$ 277.78
Cat# BP6686c
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