|Other Names||Exportin-6, Exp6, Ran-binding protein 20, XPO6, KIAA0370, RANBP20|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6688b was selected from the C-term region of human XPO6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.|
|Cellular Location||Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm|
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Provided below are standard protocols that you may find useful for product applications.
Exportins, such as XPO6, recruit cargo in the nucleoplasm in the presence of RAN (MIM 601179)-GTP and form ternary export complexes. These complexes are transported through nuclear pore complexes to the cytoplasm, where GTP is hydrolyzed and the export complex is disassembled.
Beausoleil,S.A., Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135 (2004)Stuven,T., EMBO J. 22 (21), 5928-5940 (2003)
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