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NGLY1 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q96IV0
Other Accession NP_060767
Clone Names 81028095
Peptide ID 81028095
Additional Information
Gene ID 55768
Other Names Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase, PNGase, hPNGase, N-glycanase 1, Peptide:N-glycanase, NGLY1, PNG1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NGLY1
Synonyms PNG1
Function Specifically deglycosylates the denatured form of N- linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl- glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high- mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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NGLY1 is an enzyme that catalyzes hydrolysis ofan N(4)-(acetyl-beta-D-glucosaminyl) asparagine residue toN-acetyl-beta-D-glucosaminylamine and a peptide containing anaspartate residue. The encoded enzyme may play a role in theproteasome-mediated degradation of misfolded glycoproteins.


Altrich-VanLith, M.L., et al. J. Immunol. 177(8):5440-5450(2006)Allen, M.D., et al. J. Biol. Chem. 281(35):25502-25508(2006)Katiyar, S., et al. Mol. Biol. Cell 16(10):4584-4594(2005)

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$ 80.00
Cat# BP6689a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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