PAX4 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O43316 |
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Clone Names | 81110006 |
Other Names | Paired box protein Pax-4, PAX4 |
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Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6690c was selected from the Center region of human PAX4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PAX4 |
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Function | Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity. |
Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
PAX4 is a member of the paired box (PAX) family of transcription factors. These proteins play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells.
References
Hata,S., Int. J. Oncol. 33 (5), 1065-1071 (2008)Zhang,Y., Diabetes Res. Clin. Pract. 81 (3), 365-369 (2008)
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