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RAN Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P62826
Other Accession NP_006316.1
Clone Names 81110020
Peptide ID 81110020
Additional Information
Gene ID 5901
Other Names GTP-binding nuclear protein Ran, Androgen receptor-associated protein 24, GTPase Ran, Ras-like protein TC4, Ras-related nuclear protein, RAN, ARA24
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RAN
Synonyms ARA24
Function GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensure the directionality of the transport.
Cellular Location Nucleus. Nucleus envelope. Cytoplasm. Melanosome {ECO:0000250|UniProtKB:P62827}. Note=Predominantly nuclear during interphase. Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250|UniProtKB:P62827}
Tissue Location Expressed in a variety of tissues.
Research Areas
Citations (0)

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Background

RAN (ras-related nuclear protein) is a small GTP bindingprotein belonging to the RAS superfamily that is essential for thetranslocation of RNA and proteins through the nuclear pore complex.The RAN protein is also involved in control of DNA synthesis andcell cycle progression. Nuclear localization of RAN requires thepresence of regulator of chromosome condensation 1 (RCC1).Mutations in RAN disrupt DNA synthesis. Because of its manyfunctions, it is likely that RAN interacts with several otherproteins. RAN regulates formation and organization of themicrotubule network independently of its role in thenucleus-cytosol exchange of macromolecules. RAN could be a keysignaling molecule regulating microtubule polymerization duringmitosis. RCC1 generates a high local concentration of RAN-GTParound chromatin which, in turn, induces the local nucleation ofmicrotubules. RAN is an androgen receptor (AR) coactivator thatbinds differentially with different lengths of polyglutamine withinthe androgen receptor. Polyglutamine repeat expansion in the AR islinked to Kennedy's disease (X-linked spinal and bulbar muscularatrophy). RAN coactivation of the AR diminishes with polyglutamineexpansion within the AR, and this weak coactivation may lead topartial androgen insensitivity during the development of Kennedy'sdisease.

References

Kim, J.S., et al. Mol. Carcinog. 49(10):913-921(2010)Liu, C., et al. Mol. Cell. Biol. 30(16):3956-3969(2010)Boni, V., et al. Pharmacogenomics J. (2010) In press :Ly, T.K., et al. J. Biol. Chem. 285(8):5815-5826(2010)Mishra, R.K., et al. Nat. Cell Biol. 12(2):164-169(2010)

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$ 80.00
Cat# BP6693b
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