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GSTT1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P30711
Clone Names 81020142
Additional Information
Gene ID 2952
Other Names Glutathione S-transferase theta-1, GST class-theta-1, Glutathione transferase T1-1, GSTT1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6702b was selected from the C-term region of human GSTT1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GSTT1
Function Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy- 3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.
Cellular Location Cytoplasm.
Tissue Location Found in erythrocyte. Expressed at low levels in liver. In lung, expressed at low levels in club cells and ciliated cells at the alveolar/bronchiolar junction. Absent from epithelial cells of larger bronchioles.
Research Areas
Citations (0)
citation

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Background

Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis.

References

Jones,B.A., Cancer Epidemiol (2009)Mainwaring,G.W., Biochem. J. 318 (PT 1), 297-303 (1996)

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$ 277.78
Cat# BP6702b
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Availability: 2 weeks
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