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KRT10 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P13645
Clone Names 80917037
Additional Information
Gene ID 3858
Other Names Keratin, type I cytoskeletal 10, Cytokeratin-10, CK-10, Keratin-10, K10, KRT10, KPP
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6704a was selected from the N-term region of human KRT10. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KRT10
Synonyms KPP
Function Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). Involved in the maintenance of cell layer development and keratin filament bundles in suprabasal cells of the epithelium (By similarity).
Cellular Location Secreted, extracellular space. Cell surface. Cytoplasm
Tissue Location Seen in all suprabasal cell layers including stratum corneum. Expressed on the surface of lung cell lines (PubMed:19627498). Localized on the surface of desquamated nasal epithelial cells (at protein level) (PubMed:12427098)
Research Areas
Citations (0)
citation

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Background

KRT10 is a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in its gene are associated with epidermolytic hyperkeratosis.

References

Morais,P., Eur J Dermatol 19 (4), 333-336 (2009)Barcelos,A.C., J. Cutan. Pathol. 36 (6), 647-654 (2009)

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$ 277.78
Cat# BP6704a
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