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SERPIND1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P05546 |
|---|
| Gene ID | 3053 |
|---|---|
| Other Names | Heparin cofactor 2, Heparin cofactor II, HC-II, Protease inhibitor leuserpin-2, HLS2, Serpin D1, SERPIND1, HCF2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SERPIND1 |
|---|---|
| Synonyms | HCF2 |
| Function | Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan- independent manner. |
| Tissue Location | Expressed predominantly in liver. Also present in plasma |
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Provided below are standard protocols that you may find useful for product applications.
Background
SERPIND1 is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in its gene are associated with heparin cofactor II deficiency.
References
Huang,S.S., Coron. Artery Dis. 19 (8), 597-602 (2008)Giri,T.K., Blood 107 (7), 2753-2758 (2006)
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