|Other Names||Heparin cofactor 2, Heparin cofactor II, HC-II, Protease inhibitor leuserpin-2, HLS2, Serpin D1, SERPIND1, HCF2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6706c was selected from the Center region of human SERPIND1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.|
|Tissue Location||Expressed predominantly in liver. Also present in plasma|
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Provided below are standard protocols that you may find useful for product applications.
SERPIND1 is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in its gene are associated with heparin cofactor II deficiency.
Huang,S.S., Coron. Artery Dis. 19 (8), 597-602 (2008)Giri,T.K., Blood 107 (7), 2753-2758 (2006)
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