|Other Names||Mastermind-like protein 3, Mam-3, MAML3 (HGNC:16272)|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6719b was selected from the C-term region of human MAML3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.|
|Cellular Location||Nucleus speckle. Note=Nuclear, in a punctate manner|
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Provided below are standard protocols that you may find useful for product applications.
MAML3 acts as a transcriptional coactivator for NOTCH proteins. The protein has been shown to amplify NOTCH-induced transcription of HES1.
Tonon,G., Nat. Genet. 33 (2), 208-213 (2003)Lin,S.E., J. Biol. Chem. 277 (52), 50612-50620 (2002)
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