|Other Names||Peptidyl-prolyl cis-trans isomerase FKBP2, PPIase FKBP2, 13 kDa FK506-binding protein, 13 kDa FKBP, FKBP-13, FK506-binding protein 2, FKBP-2, Immunophilin FKBP13, Rotamase, FKBP2, FKBP13|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6730a was selected from the N-term region of human FKBP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein|
|Tissue Location||T-cells and thymus.|
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Provided below are standard protocols that you may find useful for product applications.
FKBP2 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds.
Padilla,P.I., Proc. Natl. Acad. Sci. U.S.A. 100 (5), 2322-2327 (2003)Bush,K.T., Biochem. J. 303 (PT 3), 705-708 (1994)
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