|Other Names||Aminomethyltransferase, mitochondrial, Glycine cleavage system T protein, GCVT, AMT, GCST|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6739a was selected from the N-term region of human AMT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The glycine cleavage system catalyzes the degradation of glycine.|
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Provided below are standard protocols that you may find useful for product applications.
The enzyme system for cleavage of glycine (glycine cleavage system; EC 22.214.171.124), which is confined to the mitochondria, is composed of 4 protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase; MIM 238300), H protein (a lipoic acid-containing protein; MIM 238330), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase; MIM 238331). Glycine encephalopathy (GCE; MIM 605899) may be due to a defect in any one of these enzymes.
Nanao,K., Genomics 19 (1), 27-30 (1994)
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