TOMM70A Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O94826 |
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Clone Names | 81110062 |
Gene ID | 9868 |
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Other Names | Mitochondrial import receptor subunit TOM70, Mitochondrial precursor proteins import receptor, Translocase of outer membrane 70 kDa subunit, TOMM70A, KIAA0719, TOM70 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6745b was selected from the C-term region of human TOMM70A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TOMM70 (HGNC:11985) |
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Function | Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) (PubMed:12526792). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:12526792, PubMed:35025629). Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (PubMed:20628368, PubMed:25609812, PubMed:32728199). Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis (PubMed:25609812). |
Cellular Location | Mitochondrion outer membrane; Single-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
The translocase of outer mitochondrial membrane (TOM) complex is a multisubunit complex involved in the recognition, unfolding, and translocation of preproteins into the mitochondria.
References
Blesa,J.R., Gene 427 (1-2), 58-64 (2008)Chou,C.H., Mol. Biol. Cell 17 (9), 3952-3963 (2006)Edmonson,A.M., Cell Commun. Adhes. 9 (1), 15-27 (2002)
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