DUSP23 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9BVJ7 |
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Clone Names | 80311169 |
Gene ID | 54935 |
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Other Names | Dual specificity protein phosphatase 23, Low molecular mass dual specificity phosphatase 3, LDP-3, VH1-like phosphatase Z, DUSP23, LDP3, VHZ |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6749b was selected from the C-term region of human DUSP23. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DUSP23 |
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Synonyms | LDP3, VHZ |
Function | Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14). |
Cellular Location | Cytoplasm, cytosol. Nucleus. Note=Mainly cytosolic. Also nuclear |
Tissue Location | Widely expressed. Highly expressed in spleen, prostate, colon, adrenal gland, mammary gland, thyroid and trachea Expressed at lower level in uterus, small intestine, bladder, bone marrow, brain, spinal cord and stomach. |
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Provided below are standard protocols that you may find useful for product applications.
Background
DUSP23 is a protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro.This protein is able to enhance activation of JNK and p38 (MAPK14).
References
Gregory,S.G., et.al.,Nature 441 (7091), 315-321 (2006)
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