|Other Names||Fibroblast growth factor 12, FGF-12, Fibroblast growth factor homologous factor 1, FHF-1, Myocyte-activating factor, FGF12, FGF12B, FHF1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6750a was selected from the N-term region of human FGF12. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation.|
|Tissue Location||Brain, eye and testis; highly expressed in embryonic retina, olfactory epithelium, olfactory bulb, and in a segmental pattern of the body wall; in adult olfactory bulb, less in cerebellum, deep cerebellar nuclei, cortex and multiple midbrain structures|
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Provided below are standard protocols that you may find useful for product applications.
FGF12 is probably involved in nervous system development and function.
Nakayama,F., et.al., J. Radiat. Res. 49 (5), 491-501 (2008)
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