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IGFBP-6 Antibody (Center H85) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P24592 |
|---|---|
| Clone Names | 81202048 |
| Gene ID | 3489 |
|---|---|
| Other Names | Insulin-like growth factor-binding protein 6, IBP-6, IGF-binding protein 6, IGFBP-6, IGFBP6, IBP6 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6764c was selected from the Center region of human IGFBP-6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | IGFBP6 (HGNC:5475) |
|---|---|
| Synonyms | IBP6 |
| Function | IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration (PubMed:24003225). |
| Cellular Location | Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
IGFBP6 (IGF binding protein 6) is a member of the IGFBP family that regulates the actions of IGFs. It acts extracellularly in an autocrine/paracrine manner. IGFBP6 binds preferentially to IGF-II. IGFBP6 has been shown to inhibit the growth of tumour cells and to promote apotosis.
References
Guey,L.T., et.al., Eur. Urol. (2009)
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