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LGI1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O95970 |
|---|---|
| Clone Names | 81202070 |
| Gene ID | 9211 |
|---|---|
| Other Names | Leucine-rich glioma-inactivated protein 1, Epitempin-1, LGI1, EPT |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6769c was selected from the Center region of human LGI1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | LGI1 |
|---|---|
| Synonyms | EPT |
| Function | Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival. |
| Cellular Location | Secreted. Synapse {ECO:0000250|UniProtKB:Q8K4Y5}. Cytoplasm {ECO:0000250|UniProtKB:Q9JIA1} [Isoform 2]: Endoplasmic reticulum. Cytoplasm {ECO:0000250|UniProtKB:Q9JIA1} |
| Tissue Location | Predominantly expressed in neural tissues, especially in brain. Expression is reduced in low-grade brain tumors and significantly reduced or absent in malignant gliomas [Isoform 3]: Abundantly expressed in the occipital cortex and weakly expressed in the hippocampus (at protein level) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
LGI1 contains a hydrophobic segment representing a putative transmembrane domain with the amino terminus located outside the cell. It also contains leucine-rich repeats with conserved cysteine-rich flanking sequences.
References
de Bellescize,J., et.al., Epilepsy Res. 85 (1), 118-122 (2009)
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