|Other Names||Microtubule-associated protein RP/EB family member 1, APC-binding protein EB1, End-binding protein 1, EB1, MAPRE1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.|
|Cellular Location||Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Associated with the microtubule network at the growing distal tip of microtubules. Also enriched at the centrosome|
|Tissue Location||Ubiquitously expressed.|
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The protein encoded by this gene was first identified byits binding to the APC protein which is often mutated in familialand sporadic forms of colorectal cancer. This protein localizes tomicrotubules, especially the growing ends, in interphase cells.During mitosis, the protein is associated with the centrosomes andspindle microtubules. The protein also associates with componentsof the dynactin complex and the intermediate chain of cytoplasmicdynein. Because of these associations, it is thought that thisprotein is involved in the regulation of microtubule structures andchromosome stability. This gene is a member of the RP/EB family.
Jaulin, F., et al. J. Cell Biol. 190(3):443-460(2010)Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :De Groot, C.O., et al. J. Biol. Chem. 285(8):5802-5814(2010)Jiang, K., et al. EMBO Rep. 10(8):857-865(2009)Honnappa, S., et al. Cell 138(2):366-376(2009)
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