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MEP50 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9BQA1
Other Accession NP_077007.1
Clone Names 81202108
Peptide ID 81202108
Additional Information
Gene ID 79084
Other Names Methylosome protein 50, MEP-50, Androgen receptor cofactor p44, WD repeat-containing protein 77, p44/Mep50, WDR77, MEP50, WD45
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name WDR77
Synonyms MEP50, WD45
Function Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.
Cellular Location Nucleus. Cytoplasm. Note=Nuclear in Leydig cells and cytoplasmic in germ cells during fetal testicular development. In adult testis, predominantly nuclear. Subcellular location varies from nuclear to cytoplasmic in various tumors
Tissue Location Highly expressed in heart, skeletal muscle, spleen, testis, uterus, prostate and thymus. In testis, expressed in germ cells and Leydig cells, but not in peritubular myocytes, nor in Sertoli cells. Expressed in prostate cancers, in seminomas and in Leydig cell tumors.
Research Areas
Citations (0)

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WDR77 is a component of the 20S PRMT5 (MIM604045)-containing methyltransferase complex, which modifiesspecific arginines to dimethylarginines in several spliceosomal Smproteins (see MIM 601061). This modification targets Sm proteins tothe survival of motor neurons (SMN) complex (see MIM 600354) forassembly into small nuclear ribonucleoprotein core particles(Friesen et al., 2002 [PubMed 11756452]).


Vascotto, C., et al. Mol. Cell. Biol. 29(7):1834-1854(2009)Peng, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 105(13):5236-5241(2008)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Liang, J.J., et al. J. Urol. 177(5):1918-1922(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)

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$ 80.00
Cat# BP6771a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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