|Other Names||Thrombomodulin, TM, Fetomodulin, CD141, THBD, THRM|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6779c was selected from the Center region of human Thrombomodulin. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Endothelial cells are unique in synthesizing thrombomodulin|
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Provided below are standard protocols that you may find useful for product applications.
Thrombomodulin is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated.
Kajimoto,H., et.al., Circ. J. 73 (9), 1705-1710 (2009)
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