EDNRB Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P24530 |
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Clone Names | 80513110 |
Gene ID | 1910 |
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Other Names | Endothelin B receptor, ET-B, ET-BR, Endothelin receptor non-selective type, EDNRB, ETRB |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6789b was selected from the C-term region of human EDNRB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | EDNRB (HGNC:3180) |
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Synonyms | ETRB |
Function | Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
Cellular Location | Cell membrane; Multi-pass membrane protein. Note=internalized after activation by endothelins. |
Tissue Location | Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
EDNRB is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene.
References
MacClellan,L.R., et.al., Stroke 40 (10), E550-E557 (2009)
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