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HMGCS2 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P54868
Clone Names 80513200
Peptide ID 80513200
Additional Information
Gene ID 3158
Other Names Hydroxymethylglutaryl-CoA synthase, mitochondrial, HMG-CoA synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, HMGCS2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6793b was selected from the C-term region of human HMGCS2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
Cellular Location Mitochondrion.
Tissue Location Expression in liver is 200-fold higher than in any other tissue. Low expression in colon, kidney, testis, and pancreas. Very low expression in heart and skeletal muscle. Not detected in brain. The relative expression of isoform 3 (at mRNA level) is highest in heart (70%) and skeletal muscle (60%)
Research Areas
Citations (0)

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HMGCS2 belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting.


Lu,Y.,, J. Lipid Res. 49 (12), 2582-2589 (2008)

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$ 80.00
Cat# BP6793b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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