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MTMR2 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q13614
Other Accession NP_057240
Clone Names 2020711
Peptide ID 2020711
Additional Information
Gene ID 8898
Other Names Myotubularin-related protein 2, Phosphatidylinositol-3, 5-bisphosphate 3-phosphatase, Phosphatidylinositol-3-phosphate phosphatase, MTMR2, KIAA1073
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6802a was selected from the N-term region of human MTMR2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MTMR2
Synonyms KIAA1073
Function Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate.
Cellular Location Cytoplasm. Early endosome membrane; Peripheral membrane protein. Note=Partly associated with membranes. {ECO:0000269|PubMed:12668758, ECO:0000269|PubMed:21372139, ECO:0000305}
Research Areas
Citations (0)

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The MTMR2 gene encodes a member of the myotubularin family, characterized by the presence of a phosphatase domain. Mutations in the myotubularin gene (MTM) cause X-linked myotubular myopathy. Northern blot analysis reveals that the 4-kb MTMR2 mRNA is expressed ubiquitously. The mouse Mtmr2 gene encodes a 643-amino acid protein that shares 97% sequence identity with the human protein. Mouse Mtmr2 dephosphorylates phosphatidylinositol 3-phosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI3,5P2), most effectively at neutral pH. This is distinct from the activity of myotubularin, which only acts on PI3P. Analysis of MTMR2 mutations associated with Charcot-Marie-Tooth disease type 4B (CMT4B1) show markedly diminished phosphatase activity, suggesting that this activity is crucial for the proper functioning of peripheral nerves. MTMR2 mutations may lead to malfunction of neural membrane recycling, membrane trafficking, and endo- and exocytic processes. Loss-of-function mutations in MTMR2 are associated with the CMT4B phenotype. MTMR2 interacts with MTMR5, and mutations in the coiled-coil domain of either MTMR2 or MTMR5 abolish this interaction. Through this interaction, MTMR5 promotes enzymatic activity of MTMR2 and prescribe subcellular localization.


Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).Kikuno, R., et al., DNA Res. 6(3):197-205 (1999).Laporte, J., et al., Hum. Mol. Genet. 7(11):1703-1712 (1998).Laporte, J., et al., Nat. Genet. 13(2):175-182 (1996).

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$ 80.00
Cat# BP6802a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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