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CRYL1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y2S2 |
|---|---|
| Clone Names | 81006057 |
| Gene ID | 51084 |
|---|---|
| Other Names | Lambda-crystallin homolog, L-gulonate 3-dehydrogenase, Gul3DH, CRYL1, CRY |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6802b was selected from the C-term region of human CRYL1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CRYL1 |
|---|---|
| Synonyms | CRY |
| Function | Has high L-gulonate 3-dehydrogenase activity. It also exhibits low dehydrogenase activity toward L-3-hydroxybutyrate (HBA) and L-threonate. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P14755}. |
| Tissue Location | Widely expressed, with highest levels in liver and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The uronate cycle functions as an alternative glucose metabolic pathway, accounting for about 5% of daily glucose catabolism. This protein catalyzes the dehydrogenation of L-gulonate into dehydro-L-gulonate in the uronate cycle. The enzyme requires NAD(H) as a coenzyme, and is inhibited by inorganic phosphate.
References
Ishikura,S., et.al., J. Biochem. 137 (3), 303-314 (2005)
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