|Other Names||Myotubularin-related protein 3, FYVE domain-containing dual specificity protein phosphatase 1, FYVE-DSP1, Phosphatidylinositol-3, 5-bisphosphate 3-phosphatase, Phosphatidylinositol-3-phosphate phosphatase, Zinc finger FYVE domain-containing protein 10, MTMR3, KIAA0371, ZFYVE10|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6803a was selected from the C-term region of human MTMR3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (PubMed:10733931).|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
MRMT3 is a dual-specificity protein phosphatase that can dephosphorylate proteins at serine, threonine, and tyrosine residues. This protein is structurally similar to myotubularin but in addition contains a FYVE domain, a double zinc finger motif which specifically binds phosphatidylinositol(3)-phosphate. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm.
Laporte, J., et al., Biochem. Biophys. Res. Commun. 291(2):305-312 (2002).Walker, D.M., et al., Curr. Biol. 11(20):1600-1605 (2001).Zhao, R., et al., Biochem. Biophys. Res. Commun. 270(1):222-229 (2000).Laporte, J., et al., Hum. Mol. Genet. 7(11):1703-1712 (1998).Laporte, J., et al., Nat. Genet. 13(2):175-182 (1996).
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