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MTMR3 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q13615 |
|---|---|
| Clone Names | 2022502 |
| Gene ID | 8897 |
|---|---|
| Other Names | Myotubularin-related protein 3, FYVE domain-containing dual specificity protein phosphatase 1, FYVE-DSP1, Phosphatidylinositol-3, 5-bisphosphate 3-phosphatase, Phosphatidylinositol-3-phosphate phosphatase, Zinc finger FYVE domain-containing protein 10, MTMR3, KIAA0371, ZFYVE10 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6803a was selected from the C-term region of human MTMR3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MTMR3 (HGNC:7451) |
|---|---|
| Synonyms | KIAA0371, ZFYVE10 |
| Function | Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:11676921). Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5- bisphosphate (PubMed:11676921). May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (PubMed:10733931). |
| Cellular Location | Cytoplasm. Membrane; Peripheral membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
MRMT3 is a dual-specificity protein phosphatase that can dephosphorylate proteins at serine, threonine, and tyrosine residues. This protein is structurally similar to myotubularin but in addition contains a FYVE domain, a double zinc finger motif which specifically binds phosphatidylinositol(3)-phosphate. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm.
References
Laporte, J., et al., Biochem. Biophys. Res. Commun. 291(2):305-312 (2002).Walker, D.M., et al., Curr. Biol. 11(20):1600-1605 (2001).Zhao, R., et al., Biochem. Biophys. Res. Commun. 270(1):222-229 (2000).Laporte, J., et al., Hum. Mol. Genet. 7(11):1703-1712 (1998).Laporte, J., et al., Nat. Genet. 13(2):175-182 (1996).
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