|Other Names||CUE domain-containing protein 2, CUEDC2, C10orf66|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6803b was selected from the C-term region of human CUEDC2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors|
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Provided below are standard protocols that you may find useful for product applications.
CUEDC2 controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation.
Grupe,A., et.al., Am. J. Hum. Genet. 78 (1), 78-88 (2006)
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