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CUEDC2 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9H467
Clone Names 81006061
Peptide ID 81006061
Additional Information
Gene ID 79004
Other Names CUE domain-containing protein 2, CUEDC2, C10orf66
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6803b was selected from the C-term region of human CUEDC2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CUEDC2
Synonyms C10orf66
Function Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.
Cellular Location Cytoplasm. Nucleus
Tissue Location Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors
Research Areas
Citations (0)

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Background

CUEDC2 controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation.

References

Grupe,A., et.al., Am. J. Hum. Genet. 78 (1), 78-88 (2006)

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$ 80.00
Cat# BP6803b
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